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(S)-2-amino-5-guanidino-pentanoic acid

L-Arginine

CAS: 74-79-3

Molecular Formula: C6H14N4O2

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  5. (S)-2-amino-5-guanidino-pentanoic acid

(S)-2-amino-5-guanidino-pentanoic acid - Names and Identifiers

Name L-Arginine
Synonyms Arg
ABL2
FLJ31718
FLJ22224
Arginine
FLJ41441
H-Arg-OH
L-Arginine
L(+)Arginine
L(+)-Arginine
L-Arginine base
Abelson tyrosine-protein kinase 2
2-amino-5-guanidino-pentanoic acid
L-2-Amino-5-guanidinopentanoic acid
ANTI-ABL2 antibody produced in mouse
(S)-2-Amino-5-guanidinopentanoic acid
(S)-2-amino-5-guanidino-pentanoic acid
ABL2 (38-end), active, His tagged human
Abelson murine leukemia viral oncogene homolog 2
(2S)-5-{[amino(iminio)methyl]amino}-2-ammoniopentanoate
CAS 74-79-3
EINECS 200-811-1
InChI InChI=1/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/p+1/t4-/m0/s1
InChIKey ODKSFYDXXFIFQN-BYPYZUCNSA-N

(S)-2-amino-5-guanidino-pentanoic acid - Physico-chemical Properties

Molecular FormulaC6H14N4O2
Molar Mass174.2
Density1.2297 (rough estimate)
Melting Point222 °C (dec.) (lit.)
Boling Point305.18°C (rough estimate)
Specific Rotation(α)27.1 º (c=8, 6N HCl)
Flash Point201.2°C
JECFA Number1438
Water Solubility148.7 g/L (20 ºC)
Solubility H2O: 100mg/mL
Vapor Presure7.7E-08mmHg at 25°C
Appearancepowder
Colorwhite
Maximum wavelength(λmax)['λ: 260 nm Amax: ≤0.2',
, 'λ: 280 nm Amax: ≤0.1']
Merck14,780
BRN1725413
pKa1.82, 8.99, 12.5(at 25℃)
PH10.5-12.0 (25℃, 0.5M in H2O)
Storage Condition2-8°C
StabilityStable. Incompatible with strong oxidizing agents.
SensitiveAir Sensitive
Refractive Index27 ° (C=8, 6mol/L HC
MDLMFCD00002635
Physical and Chemical PropertiesHydrochloride is white or hydrochloride nearly white crystalline powder, odorless, bitter taste. 218 C when baking, 225 C when the solid state. Melting point 235 °c (decomposition). Soluble in water, soluble in hot ethanol, insoluble in ether.
UseArginine is an essential amino acid for the growth and development of infants and young children. It is an intermediate metabolite of the ornithine cycle that promotes the conversion of ammonia to urea, thereby reducing blood ammonia levels. It is also the main component of sperm protein, which promotes sperm production and provides energy for sperm movement. In addition, intravenous arginine, can stimulate the pituitary growth hormone release, can be used for pituitary function test.

(S)-2-amino-5-guanidino-pentanoic acid - Risk and Safety

Risk CodesR36 - Irritating to the eyes
R36/37/38 - Irritating to eyes, respiratory system and skin.
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R61 - May cause harm to the unborn child
Safety DescriptionS24/25 - Avoid contact with skin and eyes.
S36 - Wear suitable protective clothing.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S53 - Avoid exposure - obtain special instructions before use.
S39 - Wear eye / face protection.
WGK Germany3
RTECSCF1934200
FLUKA BRAND F CODES10-23
TSCAYes
HS Code29252000
Hazard ClassIRRITANT
Toxicitycyt-grh-par 100 mmol/L IJEBA6 24,460,86

(S)-2-amino-5-guanidino-pentanoic acid - Upstream Downstream Industry

Raw MaterialsGelatin
Downstream ProductsL-Arginine alpha-Ketoglutarate

(S)-2-amino-5-guanidino-pentanoic acid - Nature

Open Data Verified Data
  • This product is a white crystalline powder. Soluble in water (15%,21 ° C), slightly soluble in alcohol, insoluble in ether. Aqueous solution shows alkaline reaction, can absorb carbon dioxide from the air. 238 degrees C decomposition.
  • arginine is a semi-essential amino acid in the human body, that is, an amino acid that is less synthesized in the human body and needs to be partially supplemented from food, but is essential for maintaining the growth and development of infants. In the body it is an intermediate metabolite of the ornithine cycle, can promote the production and excretion of urea, correct ammonia poisoning and can relieve hepatic coma. Arginine is also the main component of sperm protein, which can promote sperm production and improve sperm movement energy. Widely found in pig hair, hoof nails, blood meal, gelatin, protamine, small miscellaneous fish.
Last Update：2024-01-02 23:10:35

(S)-2-amino-5-guanidino-pentanoic acid - Preparation Method

Open Data Verified Data
  1. extraction method.
  2. fermentation method.
Last Update：2022-01-01 11:10:12

(S)-2-amino-5-guanidino-pentanoic acid - Introduction

A substrate for nitric oxide synthetase that is converted to citrulline and nitric oxide (NO). Insulin release is induced by a mechanism associated with nitric oxide.
Last Update：2022-10-16 17:28:15

(S)-2-amino-5-guanidino-pentanoic acid - Use

Open Data Verified Data
  • amino acid drugs. For all kinds of liver coma and avoid the use of sodium glutamate and viral liver class abnormal alanine aminotransferase.
  • usage and dosage of intravenous drip 15~20g per day, diluted with 5% glucose injection looml, then intravenous drip, within 4H, 0.75~1. 5g orally, 3 times a day. For male infertility oral 3 months for a course of treatment, 4g per day.
Last Update：2022-01-01 11:10:13

(S)-2-amino-5-guanidino-pentanoic acid - Safety

Open Data Verified Data
  • attention should be paid to the occurrence of hyperchloremic acidosis in patients with renal dysfunction and anuria or in large doses. Too fast infusion can cause salivation, facial flushing and Vomit. Renal insufficiency or anuria with caution or disabled. Explosive liver failure, the lack of arginase, should not be used. When the liver function is not good, the enzyme activity required in the ornithine circulation is reduced, and the effect of reducing blood ammonia is not obvious.
  • under shading, sealed and preserved.
Last Update：2022-01-01 11:10:13

(S)-2-amino-5-guanidino-pentanoic acid - Reference Information

FEMA3819 | L-ARGININE
pH range of acid-base indicator discoloration 10.5 - 12
NIST chemical information information provided by: webbook.nist.gov (external link)
EPA chemical substance information information provided by: ofmpeb.epa.gov (external link)
essential amino acids L-arginine is a coding amino acid in protein synthesis, which belongs to one of the 8 essential amino acids in human body. The body needs it to perform multiple functions. For example, it stimulates the body to release specific chemicals such as insulin and human growth hormone. This amino acid also helps to remove ammonia from the body and promotes wound healing. It is also required for the production of sarcosine by the human body. Nitric oxide is produced when L-arginine is broken down, thus dilating vascular disease and increasing blood flow. Normally, the body itself produces enough L-arginine. But in case of deficiency, it can be supplemented by eating foods rich in arginine. L-arginine can be found in any protein-containing food, such as meat, poultry, cheese products, fish, etc. Arginine-rich foods include almonds, walnuts, dried sunflower kernels, dark chocolate, chickpeas, melon, peanuts, green lentils, hazelnuts, Brazil nuts, red meat (moderate), cashew nuts, salmon, pistachio, soy and walnut.
This year, many people have taken L-arginine supplements to treat certain diseases, such as congestive heart failure and cystitis. Although there are many benefits, but there are also some potential side effects, such as Abdominal Pain, Diarrhea, gout and abdominal distension, and may increase the severity of herpes outbreaks and strengthen the effect of antihypertensive drugs, causes a decrease in blood pressure beyond the expected range, causing dizziness and fainting in hypertensive patients.
identification test take 0.1% ml of sample solution and add 1 ml of ninhydrin test solution (TS-250), which should be reddish purple.
content analysis accurately weigh about 200mg of sample, dissolve in 3ml formic acid and 50ml glacial acetic acid, two drops of crystal violet test solution (TS-74) were added and titrated with 0.1mol/L perchloric acid to the green end point, or the blue color completely disappeared. Perchloric acid corresponds to 8.710mg of L-arginine (C6H14N4O2) per Ml of 0.1mol/L.
toxicity can be used safely in foods (FDA § 172.320,2000).
usage limit accounts for 6.6% of the total protein in food (FDA § 172.320,2000). FEMA(mg/kg): baked products, breakfast cereals, 20~100; Non-alcoholic beverages, alcoholic beverages, 3~30; Cheese, sauce, meat products, nut products, poultry products, 15~100; Gum, candy, frosting, gelatin and pudding, soft candy, sugar substitute, sweet sauce, 3~15; Condiment 2~25; Egg products, milk substitute, other cereals, 5~10; Fats, cold drinks, fruit ice, dairy products, 5~15; Fish products 15~30; Hard Candy 1~20; Instant coffee and tea 10~100; Jam, jelly, processed fruits, 2~15; Processed vegetables 3~5; Rehydrated vegetables 5~25; Spices 10~250; Snack food 15~250; Soup 5~250.
Use used in biochemical studies, various types of hepatic coma and viral liver alanine aminotransferase abnormalities.
nutritional supplements; Flavoring agents. Special flavor substances can be obtained by heating reaction with sugar (amino-carbonyl reaction). GB 2760-2001 provides for the permitted use of food flavors. An important component of amino acid infusion and comprehensive amino acid preparation.
amino acid drugs.
used as pharmaceutical raw materials and food additives
arginine is an essential amino acid for maintaining the growth and development of infants. It is an intermediate metabolite of the ornithine cycle that promotes the conversion of ammonia to urea, thereby reducing blood ammonia levels. It is also the main component of sperm protein, which promotes sperm production and provides energy for sperm movement. In addition, intravenous arginine, can stimulate the pituitary growth hormone release, can be used for pituitary function test.
nutritional supplements; Flavoring agents. Special flavor substances can be obtained by heating reaction with sugar (amino-carbonyl reaction). GB 2760-2001 provides for the permitted use of food flavors. An important component of amino acid infusion and comprehensive amino acid preparation.
The substrate of nitric oxide synthase can be converted to citrulline and NO. Insulin secretion is induced by a NO-dependent mechanism.
production method with gelatin or pig hair, pig blood powder as raw materials, after hydrolysis, the acid hydrochloride is extracted from the hydrolysate (see 03400) and the hydrochloric acid is removed to obtain the final product.
From protein (e. G., gelatin) hydrolysates by ion exchange resin or barium hydroxide separation. It is usually made into hydrochloride, but it is also stable in the Free State, so there are also free products for sale. It can also be obtained by fermentation using sugars as raw materials.
with gelatin as raw material, after hydrochloric acid hydrolysis and condensation with benzaldehyde, benzylidene arginine was obtained, which was purified by hydrochloric acid hydrolysis, activated carbon treatment and column chromatography.
category toxic substances
toxicity grade poisoning
Acute toxicity Reference range: intraperitoneal-rat LD50: 3793 mg/kg
flammability hazard characteristics flammability; Toxic NOx smoke from combustion
storage and transportation characteristics warehouse ventilation and low temperature drying
fire extinguishing agent dry powder, foam, sand, carbon dioxide, water mist
Occupational Standard SEL 10 mg/m3
toxic substance data information provided by: pubchem.ncbi.nlm.nih.gov (external link)
Last Update：2024-09-26 08:48:40
(S)-2-amino-5-guanidino-pentanoic acid
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Shanghai Yuanye Bio-Technology Co., Ltd.
Featured ProductsMultiple SpecificationsSpot supply
Product Name: L-Arginine Visit Supplier Webpage Request for quotation
CAS: 74-79-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
JIANGSU BSECHEM CHEMICAL TECHNOLOGY CO., LTD.
Spot supply
Product Name: L-Arginine Request for quotation
CAS: 74-79-3
Tel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685 Click to send a QQ messageSend QQ message
Nantong Reform Petro-Chemical CO., LTD.
Spot supply
Product Name: L-Arginine Request for quotation
CAS: 74-79-3
Tel: +86-17551318830
Email: r@reformchem.com­
Mobile: +86-17551318830
QQ: 3785839865 Click to send a QQ messageSend QQ message
Jiangsu Pules Biotechnology Co.,Ltd.
Product Name: L-Arginine Request for quotation
CAS: 74-79-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
Wechat: 17505222756
Guangzhou Yuanda New Material Co.,Ltd
Product Name: L(+)-Arginine Request for quotation
CAS: 74-79-3
Tel: +86 19849939632
Email: 2470479589@qq.com
Mobile: +86 19849939632
QQ: 2470479589 Click to send a QQ message
Wechat: +86 19849939632
Hubei YoungXin Pharmaceutical Tech Co.,Ltd.
Spot supply
Product Name: L-Arginine Visit Supplier Webpage Request for quotation
CAS: 74-79-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052 Click to send a QQ message
Wechat: 15671228036
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: L-Arginine Request for quotation
CAS: 74-79-3
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
premium ingredient co.,ltd
Product Name: L-Arginine base Request for quotation
CAS: 74-79-3
Tel: 051086995770
Email: sales@premiumingredient.com
Mobile: 18652482205
QQ: 609149175 Click to send a QQ messageSend QQ message
Hebei Boyu Biotechnology CO.,Ltd.
Product Name: L-Arginine Base Request for quotation
CAS: 74-79-3
Tel: 15373643559
Email: bomyeabio@163.com
QQ: 94128680 Click to send a QQ messageSend QQ message
View History
(S)-2-amino-5-guanidino-pentanoic acid
Raw Materials for (S)-2-amino-5-guanidino-pentanoic acid
Gelatin
Downstream Products for (S)-2-amino-5-guanidino-pentanoic acid
L-Arginine alpha-Ketoglutarate
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